MARCOIL is a hidden MARkov model-based program that
predicts existence and location of potential coiled-coil
domains in protein sequences.
An exact description of the model is in preparation and
should soon be submitted for publication preliminary version
was presented as a poster at ISMB2000.
The utility of a prediction program is often best judged
by experience gathered in using it and we would welcome
comments or suggestion for improvements.
The code can be downloaded here:
(On a Mac you might need to use the option key while
clicking on the links to download as files, under UNIX the
It was tested under UNIX and LINUX and can be compiled
using the included makefile that calls the gcc compiler. A
file with Instructions for Installation and Usage is
included in the distribution and can be read online:
For testing a database of positive examples with
annotated coiled-coils (
databasePD.gz ) and a database of sequences from PDB
databaseND.gz ), from which coiled-coils were
eliminated, have been used. Lines that begin with a "<"
contain information on the sequence like accession number or
identifier or additional information. Lines that begins with
a ">" contain the coiled-coil annotation we used (the
number of domains followed by first and last position of
each domains). This line is followed by the protein
An older existing Macintosh version could be made
available on request, but has at present no user interface.
For questions and comments, Email me at
Web-Interface to Marcoil